Exploiting bias in a non-immune human antibody library to predict antigenicity
نویسندگان
چکیده
منابع مشابه
Construction and characterization of a pseudo-immune human antibody library using yeast surface display.
Lymphocytes from eight individuals out of 60 healthy donors, whose plasmas showed relatively higher antibody titer for a target antigen of death receptor 5 (DR5), were selected for the source of antibody genes to construct so called an anti-DR5 pseudo-immune human single-chain fragment variable (scFv) library on the yeast cell surface (approximately 2x10(6) diversity). Compared with a large non...
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ژورنال
عنوان ژورنال: Protein Engineering Design and Selection
سال: 2011
ISSN: 1741-0126,1741-0134
DOI: 10.1093/protein/gzr046